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Effect of obesity on plasma homocysteine

Research Department of Human Nutrition Centre of Advanced Food Studies The Royal Veterinary & Agricultural University 1958 Frederiksberg Denmark E-mail: ast{at}kvl.dk

Dear Sir:

I read with great interest the cross-sectional study by Saw et al (1), who found several relevant determinants of plasma homocysteine concentrations in Chinese subjects. Several dietary and lifestyle factors were addressed in the analyses, but I wonder why the putative effect of body weight or body mass index was not considered. Increased body fatness may be associated with increased plasma homocysteine (2), and the study seems to have been well suited to investigate this effect. The authors should also consider body mass index as a confounder in the associations they found between age and sex and plasma homocysteine.

REFERENCES

1. Saw S-M, Yuan J-M, Ong C-N, et al. Genetic, dietary, and other lifestyle determinants of plasma homocysteine concentrations in middle-aged and older Chinese men and women in Singapore. Am J Clin Nutr 2001;73:232–9.[Abstract/Free Full Text]
2. Jacques PF, Bostom AG, Wilson PWF, Rich S, Rosenberg IH, Selhub J. Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort. Am J Clin Nutr 2001;73:613–21.[Abstract/Free Full Text]

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