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American Journal of Clinical Nutrition, Vol. 80, No. 4, 1084, October 2004
© 2004 American Society for Clinical Nutrition

LETTERS TO THE EDITOR

Supplementation with zinc and other minerals

Richard J Walden

University College London
126 Bluehouse Lane
Limpsfield, Surrey RH8 0AR
United Kingdom
E-mail: richard{at}walden60.fsnet.co.uk

Dear Sir:

I would like to comment on the interesting and important study by Penny et al (1) on the effect of supplementation with zinc or multiple micronutrients in young Peruvian children. It is important to know whether zinc was administered separately from the other minerals. Interaction, certainly with iron, would be expected, and that could explain the lower plasma concentrations of zinc in the multiple-micronutrient treatment group. It is recommended that zinc be given alone, on an empty stomach, and preferably at night for best absorption.

There are some essential micronutrients not included in the multiple formula used in this study, and it is possible that their absence affected the outcome. The missing minerals include calcium, chromium, manganese, and iodine. It may be worth commenting also that the amounts of vitamin B-12 and folate given were high, and that tartrazine is a substance best avoided.

These considerations suggest the need for another, similar study, to include the full range of essential substances and with zinc given separately and at night.

REFERENCE

  1. Penny ME, Marin RM, Duran A, et al. Randomized controlled trial of the effect of daily supplementation with zinc or multiple micronutrients on the morbidity, growth, and micronutrient status of young Peruvian children. Am J Clin Nutr 2004;79:457–65.[Abstract/Free Full Text]




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