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American Journal of Clinical Nutrition, Vol. 84, No. 2, 461-462, August 2006
© 2006 American Society for Nutrition

LETTER TO THE EDITOR

Reply to SD Phinney

Irena King, Rozenn Lemaitre and Mark Kestin

Public Health Sciences
Fred Hutchinson Cancer Research Center
Seattle, WA 98109
E-mail: iking{at}fhcrc.org

Dear Sir:

We thank Phinney for his interest in our recently published study (1). Phinney predicted an increase in fasting total serum triacylglycerol in the group randomly assigned to the low-fat diet in our feeding trial of isocaloric low-fat, high-carbohydrate and moderate-fat, low-carbohydrate diets. We measured total serum triacylglycerol at baseline and at the end of the study and found an average 10% increase in triacylglycerol from baseline in the low-fat diet group. A manuscript including these results is in preparation.

Because the increase in saturated fatty acids, particularly palmitic acid (16:0), in cholesterol esters and plasma phospholipids likely resulted from endogenous biosynthesis from carbohydrates, we may infer that the proportion of palmitic acid in triacylglycerol did increase, as suggested by Phinney. However, we did not measure the fatty acid composition of serum triacylglycerol to verify this possibility. Elevated serum triacylglycerol is a known risk factor for cardiovascular disease (2). The proposition that elevated saturated fatty acids, such as myristic acid or palmitic acid, in triacylglycerol may negate the possible cardiovascular benefits of low-fat diets is an interesting one and warrants further investigation.

ACKNOWLEDGMENTS

None of the authors had a personal or financial conflict of interest.

REFERENCES

  1. King IB, Lemaitre RN, Kestin M. Effect of a low-fat diet on fatty acid composition in red cells, plasma phospholipids, and cholesterol esters: investigation of a biomarker of total fat intake. Am J Clin Nutr 2006; 83: 227–36.[Abstract/Free Full Text]
  2. Austin MA, Hokanson JE, Edwards KL. Hypertriglyceridemia as a cardiovascular risk factor. Am J Cardiol 1998; 81: 7B–12B.[Medline]




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