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FIGURE 2.. Genes influenced by n3 fatty acids and by glitazones. Key representative genes critical for inflammation and lipid metabolism are listed. In general, proinflammatory genes (left column) are suppressed by n3 fatty acids, while genes critical for lipid peroxidation, energy utilization, and lipid homeostasis are increased by n3 fatty acids (right column). Note that many genes indicated by italic letters are activated or suppressed by n3 fatty acids and glitazones in the same direction. This figure is based on data in references 14 and 3176. COX2, cyclooxygenase 2; CRP, C-reactive protein; GLUT4, glucose transporter 4; ICAM, intercellular adhesion molecule; IL, interleukin; MMP9, matrix metalloproteinase 9; PDK4, pyruvate dehydrogenase kinase 4; UCP, uncoupling protein; VCAM, vascular cell adhesion molecule; vWF, von Willebrand factor. Other abbreviations are as defined in the legend to Figure 1.
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