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American Journal of Clinical Nutrition, Vol. 87, No. 4, 1065-1066, April 2008
© 2008 American Society for Nutrition

LETTER TO THE EDITOR

Reply to JS White

Michael B Zimmermann

Human Nutrition Laboratory
Institute of Food Science and Nutrition
ETH Zurich
LFV E19 Schmelzbergstrasse 7
8092 Zurich
Switzerland
E-mail: michael.zimmermann{at}ilw.agrl.ethz.ch

Giatgen A Spinas and Kaspar Berneis

Clinic for Endocrinology and Diabetes
University Hospital Zurich
Zurich
Switzerland

Dear Sir:

The correlation between fructose and LDL particle size, after adjustment for confounders, including protein intake, was not "slight," but highly significant (P = 0.024) (1). As clearly stated in our article, the data show no effect of fructose on total and LDL cholesterol. This finding is consistent with previous data reporting correlations of LDL particle size with plasma triacylglycerols and plasma HDL, but not with LDL cholesterol (2). As we stated in our article, because a decrease in LDL particle size is one of the first detectable changes in the development of dyslipidemia (3), modulation of LDL particle size—possibly a reflection of early insulin resistance—may be an early, unfavorable metabolic effect of fructose. The low free fructose intakes in our sample are typical of what European diets provide and suggest a potent effect of even low intakes of fructose on LDL particle size.  No conflicts of interest were reported.

REFERENCES

  1. Aeberli I, Zimmermann MB, Molinari L, et al. Fructose intake is a predictor of LDL particle size in overweight schoolchildren. Am J Clin Nutr 2007;86:1174–8.[Abstract/Free Full Text]
  2. Rizzo M, Barbagallo CM, Severino M, et al. Low-density-lipoprotein peak particle size in a Mediterranean population. Eur J Clin Invest 2003;33(2):126–33.[Medline]
  3. Barbagallo CM, Rizzo M, Cefalu AB, et al. Changes in plasma lipids and low-density lipoprotein peak particle size during and after acute myocardial infarction. Am J Cardiol 2002;89:460–2.[Medline]




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